Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

The inhibitors of apoptosis (IAP) proteins cIAP1 and cIAP2 have recently emerged as key ubiquitin-E3 ligases regulating innate immunity and cell survival. Much of our knowledge of these IAPs stems from studies using pharmacological inhibitors of IAPs, dubbed Smac mimetics (SMs). Although SMs stimula...

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Detalles Bibliográficos
Autores principales: Darding, M, Feltham, R, Tenev, T, Bianchi, K, Benetatos, C, Silke, J, Meier, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172091/
https://www.ncbi.nlm.nih.gov/pubmed/21331077
http://dx.doi.org/10.1038/cdd.2011.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172091/
https://www.ncbi.nlm.nih.gov/pubmed/21331077
http://dx.doi.org/10.1038/cdd.2011.10

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