Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

We have recently reported that the bioactive lipid sphingosine-1-phosphate (S1P), usually signaling proliferation and anti-apoptosis induces neuronal death when generated by sphingosine-kinase2 and when accumulation due to S1P-lyase deficiency occurs. In the present study, we identify the signaling...

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Detalles Bibliográficos
Autores principales: Hagen, N, Hans, M, Hartmann, D, Swandulla, D, van Echten-Deckert, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172106/
https://www.ncbi.nlm.nih.gov/pubmed/21331079
http://dx.doi.org/10.1038/cdd.2011.7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172106/
https://www.ncbi.nlm.nih.gov/pubmed/21331079
http://dx.doi.org/10.1038/cdd.2011.7

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