The E92K Melanocortin 1 Receptor Mutant Induces cAMP Production and Arrestin Recruitment but Not ERK Activity Indicating Biased Constitutive Signaling

BACKGROUND: The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has b...

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Detalles Bibliográficos
Autores principales: Benned-Jensen, Tau, Mokrosinski, Jacek, Rosenkilde, Mette M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172247/
https://www.ncbi.nlm.nih.gov/pubmed/21931793
http://dx.doi.org/10.1371/journal.pone.0024644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172247/
https://www.ncbi.nlm.nih.gov/pubmed/21931793
http://dx.doi.org/10.1371/journal.pone.0024644

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