Cargando…
Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes
Protein misfolding is a common event in living cells. Molecular chaperones not only assist protein folding; they also facilitate the degradation of misfolded polypeptides. When the intracellular degradative capacity is exceeded, juxtanuclear aggresomes are formed to sequester misfolded proteins. Des...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172255/ https://www.ncbi.nlm.nih.gov/pubmed/21775628 http://dx.doi.org/10.1091/mbc.E11-05-0388 |