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EphrinA/EphA signal facilitates insulin-like growth factor-I–induced myogenic differentiation through suppression of the Ras/extracellular signal–regulated kinase 1/2 cascade in myoblast cell lines

Insulin-like growth factor-I (IGF-I) activates not only the phosphatidylinositol 3-kinase (PI3K)–AKT cascade that is essential for myogenic differentiation but also the extracellular signal–regulated kinase (ERK) 1/2 cascade that inhibits myogenesis. We hypothesized that there must be a signal that...

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Detalles Bibliográficos
Autores principales: Minami, Masayoshi, Koyama, Tatsuya, Wakayama, Yuki, Fukuhara, Shigetomo, Mochizuki, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172274/
https://www.ncbi.nlm.nih.gov/pubmed/21795402
http://dx.doi.org/10.1091/mbc.E11-03-0183