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T Cell Epitope Regions of the P. falciparum MSP1-33 Critically Influence Immune Responses and In Vitro Efficacy of MSP1-42 Vaccines

The C-terminal 42 kDa fragments of the P. falciparum Merozoite Surface Protein 1, MSP1-42 is a leading malaria vaccine candidate. MSP1-33, the N-terminal processed fragment of MSP1-42, is rich in T cell epitopes and it is hypothesized that they enhance antibody response toward MSP1-19. Here, we gave...

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Detalles Bibliográficos
Autores principales: Pusic, Kae M., Hashimoto, Caryn N., Lehrer, Axel, Aniya, Charmaine, Clements, David E., Hui, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172285/
https://www.ncbi.nlm.nih.gov/pubmed/21931852
http://dx.doi.org/10.1371/journal.pone.0024782