Origination of New Immunological Functions in the Costimulatory Molecule B7-H3: The Role of Exon Duplication in Evolution of the Immune System

B7-H3, a recently identified B7 family member, has different isoforms in human and mouse. Mouse B7-H3 gene has only one isoform (2IgB7-H3) with two Ig-like domains, whereas human B7-H3 has two isoforms (2IgB7-H3 and 4IgB7-H3). In this study a systematic genomic survey across various species from tel...

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Detalles Bibliográficos
Autores principales: Sun, Jing, Fu, Fengqing, Gu, Wenchao, Yan, Ruhong, Zhang, Guangbo, Shen, Zhiyong, Zhou, Yinghui, Wang, Han, Shen, Bairong, Zhang, Xueguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172298/
https://www.ncbi.nlm.nih.gov/pubmed/21931843
http://dx.doi.org/10.1371/journal.pone.0024751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172298/
https://www.ncbi.nlm.nih.gov/pubmed/21931843
http://dx.doi.org/10.1371/journal.pone.0024751

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