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Modelling of the outcome of non-inferiority trials by integration of historical data
The approval and differentiation of new compounds in clinical development often demands non-inferiority trials, in which the test drug is compared against a reference treatment. However, non-inferiority trials impose major operational burden with serious ethical and scientific implications for the d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172410/ https://www.ncbi.nlm.nih.gov/pubmed/21858724 http://dx.doi.org/10.1007/s10928-011-9210-8 |