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NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses

Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic n-methyl-d-aspartate receptor (NMDAR) antagonist, produces fast-acting antidepressant responses in patients suffering from major depressive disorder (MDD), although the underlying...

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Detalles Bibliográficos
Autores principales: Autry, Anita E., Adachi, Megumi, Nosyreva, Elena, Na, Elisa S., Los, Maarten F., Cheng, Peng-fei, Kavalali, Ege T., Monteggia, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172695/
https://www.ncbi.nlm.nih.gov/pubmed/21677641
http://dx.doi.org/10.1038/nature10130