Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

BACKGROUND: The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for cancer therapy but inhibitors have proved elusive....

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Detalles Bibliográficos
Autores principales: Peasland, A, Wang, L-Z, Rowling, E, Kyle, S, Chen, T, Hopkins, A, Cliby, W A, Sarkaria, J, Beale, G, Edmondson, R J, Curtin, N J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172902/
https://www.ncbi.nlm.nih.gov/pubmed/21730979
http://dx.doi.org/10.1038/bjc.2011.243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172902/
https://www.ncbi.nlm.nih.gov/pubmed/21730979
http://dx.doi.org/10.1038/bjc.2011.243

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