Timothy Mutation Disrupts the Link between Activation and Inactivation in Ca(V)1.2 Protein

The Timothy syndrome mutations G402S and G406R abolish inactivation of Ca(V)1.2 and cause multiorgan dysfunction and lethal arrhythmias. To gain insights into the consequences of the G402S mutation on structure and function of the channel, we systematically mutated the corresponding Gly-432 of the r...

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Detalles Bibliográficos
Autores principales: Depil, Katrin, Beyl, Stanislav, Stary-Weinzinger, Anna, Hohaus, Annette, Timin, Eugen, Hering, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173108/
https://www.ncbi.nlm.nih.gov/pubmed/21685391
http://dx.doi.org/10.1074/jbc.M111.255273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173108/
https://www.ncbi.nlm.nih.gov/pubmed/21685391
http://dx.doi.org/10.1074/jbc.M111.255273

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