The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse

The Bordetella pertussis adenylate cyclase toxin (CyaA) assists infection by potently suppressing the host immune response. Although CyaA effectively targets T lymphocytes, its putative receptor on these cells is unknown. Here, we show that CyaA binds to T cells via the β(2) integrin LFA-1 in its ac...

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Detalles Bibliográficos
Autores principales: Paccani, Silvia Rossi, Finetti, Francesca, Davi, Marilyne, Patrussi, Laura, D'Elios, Mario M., Ladant, Daniel, Baldari, Cosima T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173238/
https://www.ncbi.nlm.nih.gov/pubmed/21576384
http://dx.doi.org/10.1084/jem.20101558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173238/
https://www.ncbi.nlm.nih.gov/pubmed/21576384
http://dx.doi.org/10.1084/jem.20101558

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