T cell receptor signal strength in T(reg) and iNKT cell development demonstrated by a novel fluorescent reporter mouse

The ability of antigen receptors to engage self-ligands with varying affinity is crucial for lymphocyte development. To further explore this concept, we generated transgenic mice expressing GFP from the immediate early gene Nr4a1 (Nur77) locus. GFP was up-regulated in lymphocytes by antigen receptor...

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Detalles Bibliográficos
Autores principales: Moran, Amy E., Holzapfel, Keli L., Xing, Yan, Cunningham, Nicole R., Maltzman, Jonathan S., Punt, Jennifer, Hogquist, Kristin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173240/
https://www.ncbi.nlm.nih.gov/pubmed/21606508
http://dx.doi.org/10.1084/jem.20110308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173240/
https://www.ncbi.nlm.nih.gov/pubmed/21606508
http://dx.doi.org/10.1084/jem.20110308

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