Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts

BACKGROUND: Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process. We previously revealed the importance of the mevalonate cascade in the fibrotic response of human airway smooth muscle cells. We...

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Detalles Bibliográficos
Autores principales: Schaafsma, Dedmer, McNeill, Karol D, Mutawe, Mark M, Ghavami, Saeid, Unruh, Helmut, Jacques, Eric, Laviolette, Michel, Chakir, Jamila, Halayko, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173339/
https://www.ncbi.nlm.nih.gov/pubmed/21864337
http://dx.doi.org/10.1186/1465-9921-12-113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173339/
https://www.ncbi.nlm.nih.gov/pubmed/21864337
http://dx.doi.org/10.1186/1465-9921-12-113

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