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Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts

BACKGROUND: Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process. We previously revealed the importance of the mevalonate cascade in the fibrotic response of human airway smooth muscle cells. We...

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Detalles Bibliográficos
Autores principales:	Schaafsma, Dedmer, McNeill, Karol D, Mutawe, Mark M, Ghavami, Saeid, Unruh, Helmut, Jacques, Eric, Laviolette, Michel, Chakir, Jamila, Halayko, Andrew J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173339/ https://www.ncbi.nlm.nih.gov/pubmed/21864337 http://dx.doi.org/10.1186/1465-9921-12-113

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