The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice

BACKGROUND: Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The ubiquitin-proteasome pathway degrades the NFκB inhibitor IκBα, enabling NFκB t...

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Detalles Bibliográficos
Autores principales: Caron, Annabelle Z, Haroun, Sonia, Leblanc, Élisabeth, Trensz, Frédéric, Guindi, Chantal, Amrani, Aziz, Grenier, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173404/
https://www.ncbi.nlm.nih.gov/pubmed/21843349
http://dx.doi.org/10.1186/1471-2474-12-185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173404/
https://www.ncbi.nlm.nih.gov/pubmed/21843349
http://dx.doi.org/10.1186/1471-2474-12-185

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