Structure and Behavior of Human α-Thrombin upon Ligand Recognition: Thermodynamic and Molecular Dynamics Studies

Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution. Active site occupation induces large changes in secondary structure content in thrombin as show...

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Detalles Bibliográficos
Autores principales: Silva, Vivian de Almeira, Cargnelutti, Maria Thereza, Giesel, Guilherme M., Palmieri, Leonardo C., Monteiro, Robson Q., Verli, Hugo, Lima, Luis Mauricio T. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173475/
https://www.ncbi.nlm.nih.gov/pubmed/21935446
http://dx.doi.org/10.1371/journal.pone.0024735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173475/
https://www.ncbi.nlm.nih.gov/pubmed/21935446
http://dx.doi.org/10.1371/journal.pone.0024735

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