Computational Design of a DNA- and Fc-Binding Fusion Protein

Computational design of novel proteins with well-defined functions is an ongoing topic in computational biology. In this work, we generated and optimized a new synthetic fusion protein using an evolutionary approach. The optimization was guided by directed evolution based on hydrophobicity scores, m...

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Detalles Bibliográficos
Autores principales: Winkler, Jonas, Armano, Giuliano, Dybowski, J. Nikolaj, Kuhn, Oliver, Ledda, Filippo, Heider, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173724/
https://www.ncbi.nlm.nih.gov/pubmed/21941539
http://dx.doi.org/10.1155/2011/457578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173724/
https://www.ncbi.nlm.nih.gov/pubmed/21941539
http://dx.doi.org/10.1155/2011/457578

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