Hydroxyurea Therapy Mobilises Arachidonic Acid from Inner Cell Membrane Aminophospholipids in Patients with Homozygous Sickle Cell Disease

The cytotoxic compound hydroxyurea (HU) is effective therapy for sickle cell disease. However, its effect on unsaturated membrane lipids is unknown. Red cell fatty acids were investigated in HU-treated (n = 19) and HU-untreated (n = 17) sickle cell patients and controls (n = 20). The HU-treated comp...

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Detalles Bibliográficos
Autores principales: Daak, A. A., Ghebremeskel, K., Elbashir, M. I., Bakhita, A., Hassan, Z., Crawford, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173880/
https://www.ncbi.nlm.nih.gov/pubmed/21941660
http://dx.doi.org/10.1155/2011/718014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173880/
https://www.ncbi.nlm.nih.gov/pubmed/21941660
http://dx.doi.org/10.1155/2011/718014

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