Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol

[Image: see text] 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) represents a promising therapeutic target for breast cancer treatment. To reduce the undesirable estrogenic activity of potent 17β-HSD1 inhibitor 16β-(m-carbamoylbenzyl)estradiol (1) (IC(50) = 27 nM), a series of analogues with a s...

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Detalles Bibliográficos
Autores principales: Maltais, René, Ayan, Diana, Poirier, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174009/
https://www.ncbi.nlm.nih.gov/pubmed/21927646
http://dx.doi.org/10.1021/ml200093v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174009/
https://www.ncbi.nlm.nih.gov/pubmed/21927646
http://dx.doi.org/10.1021/ml200093v

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