Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries

Statins can have beneficial cholesterol-independent effects on vascular contractility, which may involve increases in the bioavailability of NO (nitric oxide) as a result of phosphorylation of eNOS (endothelial NO synthase). Although this has been attributed to phosphorylation of Akt (also known as...

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Detalles Bibliográficos
Autores principales: Rossoni, Luciana V., Wareing, Mark, Wenceslau, Camilla F., Al-Abri, Mahmood, Cobb, Chris, Austin, Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174052/
https://www.ncbi.nlm.nih.gov/pubmed/21671887
http://dx.doi.org/10.1042/CS20110259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174052/
https://www.ncbi.nlm.nih.gov/pubmed/21671887
http://dx.doi.org/10.1042/CS20110259

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