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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
BACKGROUND: Oxidative stress plays an important role in neuronal dysfunction and neuron loss in Alzheimer's brain. Previous studies have reported downregulation of CREB-mediated transcription by oxidative stress and Aβ. The promoter for CREB itself contains cyclic AMP response elements. Therefo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174124/ https://www.ncbi.nlm.nih.gov/pubmed/21854604 http://dx.doi.org/10.1186/1750-1326-6-60 |