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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

BACKGROUND: Oxidative stress plays an important role in neuronal dysfunction and neuron loss in Alzheimer's brain. Previous studies have reported downregulation of CREB-mediated transcription by oxidative stress and Aβ. The promoter for CREB itself contains cyclic AMP response elements. Therefo...

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Detalles Bibliográficos
Autores principales:	Pugazhenthi, Subbiah, Wang, Maorong, Pham, Serena, Sze, Chun-I, Eckman, Christopher B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174124/ https://www.ncbi.nlm.nih.gov/pubmed/21854604 http://dx.doi.org/10.1186/1750-1326-6-60

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