Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding

Lucanthone and hycanthone are thioxanthenone DNA intercalators used in the 1980s as antitumor agents. Lucanthone is in Phase I clinical trial, whereas hycanthone was pulled out of Phase II trials. Their potential mechanism of action includes DNA intercalation, inhibition of nucleic acid biosyntheses...

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Detalles Bibliográficos
Autores principales: Naidu, Mamta D., Agarwal, Rakhi, Pena, Louis A., Cunha, Luis, Mezei, Mihaly, Shen, Min, Wilson, David M., Liu, Yuan, Sanchez, Zina, Chaudhary, Pankaj, Wilson, Samuel H., Waring, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174134/
https://www.ncbi.nlm.nih.gov/pubmed/21935361
http://dx.doi.org/10.1371/journal.pone.0023679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174134/
https://www.ncbi.nlm.nih.gov/pubmed/21935361
http://dx.doi.org/10.1371/journal.pone.0023679

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