Predictive Power Estimation Algorithm (PPEA) - A New Algorithm to Reduce Overfitting for Genomic Biomarker Discovery

Toxicogenomics promises to aid in predicting adverse effects, understanding the mechanisms of drug action or toxicity, and uncovering unexpected or secondary pharmacology. However, modeling adverse effects using high dimensional and high noise genomic data is prone to over-fitting. Models constructe...

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Detalles Bibliográficos
Autores principales: Liu, Jiangang, Jolly, Robert A., Smith, Aaron T., Searfoss, George H., Goldstein, Keith M., Uversky, Vladimir N., Dunker, Keith, Li, Shuyu, Thomas, Craig E., Wei, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174148/
https://www.ncbi.nlm.nih.gov/pubmed/21935387
http://dx.doi.org/10.1371/journal.pone.0024233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174148/
https://www.ncbi.nlm.nih.gov/pubmed/21935387
http://dx.doi.org/10.1371/journal.pone.0024233

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