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Pseudomonas aeruginosa 4-Amino-4-Deoxychorismate Lyase: Spatial Conservation of an Active Site Tyrosine and Classification of Two Types of Enzyme

4-Amino-4-deoxychorismate lyase (PabC) catalyzes the formation of 4-aminobenzoate, and release of pyruvate, during folate biosynthesis. This is an essential activity for the growth of Gram-negative bacteria, including important pathogens such as Pseudomonas aeruginosa. A high-resolution (1.75 Å) cry...

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Detalles Bibliográficos
Autores principales: O'Rourke, Patrick E. F., Eadsforth, Thomas C., Fyfe, Paul K., Shepherd, Sharon M., Hunter, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174152/
https://www.ncbi.nlm.nih.gov/pubmed/21935381
http://dx.doi.org/10.1371/journal.pone.0024158