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Binding Leverage as a Molecular Basis for Allosteric Regulation
Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures the ability of a binding site to couple to the intrinsic motions of a protein. We...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174156/ https://www.ncbi.nlm.nih.gov/pubmed/21935347 http://dx.doi.org/10.1371/journal.pcbi.1002148 |