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Binding Leverage as a Molecular Basis for Allosteric Regulation

Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures the ability of a binding site to couple to the intrinsic motions of a protein. We...

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Detalles Bibliográficos
Autores principales: Mitternacht, Simon, Berezovsky, Igor N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174156/
https://www.ncbi.nlm.nih.gov/pubmed/21935347
http://dx.doi.org/10.1371/journal.pcbi.1002148

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