Cargando…
Binding Leverage as a Molecular Basis for Allosteric Regulation
Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures the ability of a binding site to couple to the intrinsic motions of a protein. We...
Autores principales: | Mitternacht, Simon, Berezovsky, Igor N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174156/ https://www.ncbi.nlm.nih.gov/pubmed/21935347 http://dx.doi.org/10.1371/journal.pcbi.1002148 |
Ejemplares similares
-
Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
por: Mitternacht, Simon, et al.
Publicado: (2011) -
SPACER: server for predicting allosteric communication and effects of regulation
por: Goncearenco, Alexander, et al.
Publicado: (2013) -
Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
por: Tee, Wei-Ven, et al.
Publicado: (2018) -
Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication
por: Guarnera, Enrico, et al.
Publicado: (2016) -
Disorder driven allosteric control of protein activity
por: Tee, Wei-Ven, et al.
Publicado: (2020)