Replication Protein A (RPA) Hampers the Processive Action of APOBEC3G Cytosine Deaminase on Single-Stranded DNA

BACKGROUND: Editing deaminases have a pivotal role in cellular physiology. A notable member of this superfamily, APOBEC3G (A3G), restricts retroviruses, and Activation Induced Deaminase (AID) generates antibody diversity by localized deamination of cytosines in DNA. Unconstrained deaminase activity...

Descripción completa

Detalles Bibliográficos
Autores principales: Lada, Artem G., Waisertreiger, Irina S.-R., Grabow, Corinn E., Prakash, Aishwarya, Borgstahl, Gloria E. O., Rogozin, Igor B., Pavlov, Youri I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174200/
https://www.ncbi.nlm.nih.gov/pubmed/21935481
http://dx.doi.org/10.1371/journal.pone.0024848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174200/
https://www.ncbi.nlm.nih.gov/pubmed/21935481
http://dx.doi.org/10.1371/journal.pone.0024848

Ejemplares similares