The RAG2 C-terminus suppresses genomic instability and lymphomagenesis

Misrepair of DNA double-strand breaks (DSBs) produced by the V(D)J recombinase (the RAG1/RAG2 proteins) at immunoglobulin (Ig) and T cell receptor (Tcr) loci has been implicated in pathogenesis of lymphoid malignancies in humans(1) and in mice(2–7). Defects in DNA damage response factors such as ATM...

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Detalles Bibliográficos
Autores principales: Deriano, Ludovic, Chaumeil, Julie, Coussens, Marc, Multani, Asha, Chou, YiFan, Alekseyenko, Alexander V., Chang, Sandy, Skok, Jane A., Roth, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174233/
https://www.ncbi.nlm.nih.gov/pubmed/21368836
http://dx.doi.org/10.1038/nature09755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174233/
https://www.ncbi.nlm.nih.gov/pubmed/21368836
http://dx.doi.org/10.1038/nature09755

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