Nanomolar potency and selectivity of a Ca(2+) release-activated Ca(2+) channel inhibitor against store-operated Ca(2+) entry and migration of vascular smooth muscle cells

BACKGROUND AND PURPOSE: The aim was to advance the understanding of Orai proteins and identify a specific inhibitor of the associated calcium entry mechanism in vascular smooth muscle cells (VSMCs). EXPERIMENTAL APPROACH: Proliferating VSMCs were cultured from human saphenous veins. Intracellular ca...

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Detalles Bibliográficos
Autores principales: Li, Jing, McKeown, Lynn, Ojelabi, Ogooluwa, Stacey, Martin, Foster, Richard, O'Regan, David, Porter, Karen E, Beech, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174418/
https://www.ncbi.nlm.nih.gov/pubmed/21545575
http://dx.doi.org/10.1111/j.1476-5381.2011.01368.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174418/
https://www.ncbi.nlm.nih.gov/pubmed/21545575
http://dx.doi.org/10.1111/j.1476-5381.2011.01368.x

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