Exposed Hydrophobic Residues in Human Immunodeficiency Virus Type 1 Vpr Helix-1 Are Important for Cell Cycle Arrest and Cell Death

The human immunodeficiency virus type 1 (HIV-1) accessory protein viral protein R (Vpr) is a major determinant for virus-induced G2/M cell cycle arrest and cytopathicity. Vpr is thought to perform these functions through the interaction with partner proteins. The NMR structure of Vpr revealed solven...

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Detalles Bibliográficos
Autores principales: Barnitz, R. Anthony, Chaigne-Delalande, Benjamin, Bolton, Diane L., Lenardo, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174981/
https://www.ncbi.nlm.nih.gov/pubmed/21949789
http://dx.doi.org/10.1371/journal.pone.0024924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174981/
https://www.ncbi.nlm.nih.gov/pubmed/21949789
http://dx.doi.org/10.1371/journal.pone.0024924

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