Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation

BACKGROUND: Insulin is a hormone that regulates blood glucose homeostasis and is a central protein in a medical condition termed insulin injection amyloidosis. It is intimately associated with glycaemia and is vulnerable to glycation by glucose and other highly reactive carbonyls like methylglyoxal,...

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Detalles Bibliográficos
Autores principales: Oliveira, Luis MA, Lages, Ana, Gomes, Ricardo A, Neves, Henrique, Família, Carlos, Coelho, Ana V, Quintas, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175161/
https://www.ncbi.nlm.nih.gov/pubmed/21819598
http://dx.doi.org/10.1186/1471-2091-12-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175161/
https://www.ncbi.nlm.nih.gov/pubmed/21819598
http://dx.doi.org/10.1186/1471-2091-12-41

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