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Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation
BACKGROUND: Insulin is a hormone that regulates blood glucose homeostasis and is a central protein in a medical condition termed insulin injection amyloidosis. It is intimately associated with glycaemia and is vulnerable to glycation by glucose and other highly reactive carbonyls like methylglyoxal,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175161/ https://www.ncbi.nlm.nih.gov/pubmed/21819598 http://dx.doi.org/10.1186/1471-2091-12-41 |