Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression

BACKGROUND: Previous studies showed that mesothelin (MSLN) plays important roles in survival of pancreatic cancer (PC) cells under anchorage dependent/independent conditions as well as resistance to chemotherapy. The recent success of intratumorally-injected adeno-encoded, chemo/radiation-inducible-...

Descripción completa

Detalles Bibliográficos
Autores principales: Bharadwaj, Uddalak, Marin-Muller, Christian, Li, Min, Chen, Changyi, Yao, Qizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175472/
https://www.ncbi.nlm.nih.gov/pubmed/21880146
http://dx.doi.org/10.1186/1476-4598-10-106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175472/
https://www.ncbi.nlm.nih.gov/pubmed/21880146
http://dx.doi.org/10.1186/1476-4598-10-106

Ejemplares similares