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Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression

BACKGROUND: Previous studies showed that mesothelin (MSLN) plays important roles in survival of pancreatic cancer (PC) cells under anchorage dependent/independent conditions as well as resistance to chemotherapy. The recent success of intratumorally-injected adeno-encoded, chemo/radiation-inducible-...

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Detalles Bibliográficos
Autores principales:	Bharadwaj, Uddalak, Marin-Muller, Christian, Li, Min, Chen, Changyi, Yao, Qizhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175472/ https://www.ncbi.nlm.nih.gov/pubmed/21880146 http://dx.doi.org/10.1186/1476-4598-10-106

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