Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

Most pathogenic mtDNA mutations are heteroplasmic and there is a clear correlation between high levels of mutated mtDNA in a tissue and pathology. We have found that in vivo double strand breaks (DSB) in mtDNA lead to digestion of cleaved mtDNA and replication of residual mtDNA. Therefore, if DSB co...

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Detalles Bibliográficos
Autores principales: Bacman, Sandra R., Williams, Sion L., Garcia, Sofia, Moraes, Carlos T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175591/
https://www.ncbi.nlm.nih.gov/pubmed/20220783
http://dx.doi.org/10.1038/gt.2010.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175591/
https://www.ncbi.nlm.nih.gov/pubmed/20220783
http://dx.doi.org/10.1038/gt.2010.25

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