Cargando…

Innate Immune Responses to AAV Vectors

Gene replacement therapy by in vivo delivery of adeno-associated virus (AAV) is attractive as a potential treatment for a variety of genetic disorders. However, while AAV has been used successfully in many models, other experiments in clinical trials and in animal models have been hampered by undesi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rogers, Geoffrey L., Martino, Ashley T., Aslanidi, George V., Jayandharan, Giridhara R., Srivastava, Arun, Herzog, Roland W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2011
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175613/ https://www.ncbi.nlm.nih.gov/pubmed/21954398 http://dx.doi.org/10.3389/fmicb.2011.00194

Ejemplares similares

Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B
por: Rogers, Geoffrey L, et al.
Publicado: (2014)

High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression by Optimized AAV6 Serotype Vectors In Vitro and in a Murine Xenograft Model In Vivo
por: Song, Liujiang, et al.
Publicado: (2013)

Improved ocular gene transfer with a Neddylation-site modified AAV-RPE65 vector in rd12 mice
por: Maurya, Shubham, et al.
Publicado: (2020)

Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy
por: Sen, Dwaipayan, et al.
Publicado: (2013)

Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer
por: Selot, Ruchita, et al.
Publicado: (2017)

Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors
por: Ling, Chen, et al.
Publicado: (2016)

Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo
por: Maurya, Shubham, et al.
Publicado: (2020)

MicroRNA‐based recombinant AAV vector assembly improves efficiency of suicide gene transfer in a murine model of lymphoma
por: Khan, Nusrat, et al.
Publicado: (2020)

Cellular unfolded protein response against viruses used in gene therapy
por: Sen, Dwaipayan, et al.
Publicado: (2014)

Development of an AAV DNA-based synthetic vector for the potential gene therapy of hemophilia in children
por: Shoti, Jakob, et al.
Publicado: (2022)

Immune Response Mechanisms against AAV Vectors in Animal Models
por: Martino, Ashley T., et al.
Publicado: (2019)

AAV6 Vexosomes Mediate Robust Suicide Gene Delivery in a Murine Model of Hepatocellular Carcinoma
por: Khan, Nusrat, et al.
Publicado: (2020)

Microglia-specific targeting by novel capsid-modified AAV6 vectors
por: Rosario, Awilda M, et al.
Publicado: (2016)

Activation of the Cellular Unfolded Protein Response by Recombinant Adeno-Associated Virus Vectors
por: Balakrishnan, Balaji, et al.
Publicado: (2013)

Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors
por: Basner-Tschakarjan, Etiena, et al.
Publicado: (2014)

Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?
por: Aslanidi, George V., et al.
Publicado: (2013)

Post‐translational modifications in capsid proteins of recombinant adeno‐associated virus (AAV) 1‐rh10 serotypes
por: Mary, Bertin, et al.
Publicado: (2019)

T Cell-Mediated Immune Responses to AAV and AAV Vectors
por: Ertl, Hildegund C. J.
Publicado: (2021)

Immune Responses to rAAV6: The Influence of Canine Parvovirus Vaccination and Neonatal Administration of Viral Vector
por: Arnett, Andrea L. H., et al.
Publicado: (2011)

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity
por: Bartel, Melissa, et al.
Publicado: (2011)

AAV vector production: Troublesome host innate responses in another setting
por: Wright, J. Fraser
Publicado: (2023)

AAV vector production: Troublesome host innate responses in another setting
por: Wright, J. Fraser
Publicado: (2023)

Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration
por: Colon-Cortes, Yanerys, et al.
Publicado: (2020)

Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors
por: Büning, Hildegard, et al.
Publicado: (2019)

Rational Engineering and Preclinical Evaluation of Neddylation and SUMOylation Site Modified Adeno-Associated Virus Vectors in Murine Models of Hemophilia B and Leber Congenital Amaurosis
por: Maurya, Shubham, et al.
Publicado: (2019)

Development of optimized AAV3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells
por: Cheng, Binbin, et al.
Publicado: (2011)

Tumor antigen-loaded AAV vaccine drives protective immunity in a melanoma animal model
por: Krotova, Karina, et al.
Publicado: (2023)

Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors
por: Tejero, Marcos, et al.
Publicado: (2023)

Potential for cellular stress response to hepatic factor VIII expression from AAV vector
por: Zolotukhin, Irene, et al.
Publicado: (2016)

Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy
por: Srivastava, Arun
Publicado: (2023)

Role of Essential Metal Ions in AAV Vector-Mediated Transduction
por: Rambhai, Himanshu K., et al.
Publicado: (2020)

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors
por: Ronzitti, Giuseppe, et al.
Publicado: (2020)

MicroRNA-15b Modulates Molecular Mediators of Blood Induced Arthropathy in Hemophilia Mice
por: Sen, Dwaipayan, et al.
Publicado: (2016)

Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside
por: Ferreira, Valerie, et al.
Publicado: (2014)

Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes
por: Hamilton, Bradley A., et al.
Publicado: (2021)

Effect of CpG Depletion of Vector Genome on CD8(+) T Cell Responses in AAV Gene Therapy
por: Bertolini, Thais B., et al.
Publicado: (2021)

Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
por: Kay, Christine N., et al.
Publicado: (2013)

Responses of innate immune cells to group A Streptococcus
por: Fieber, Christina, et al.
Publicado: (2014)

Editorial: Virus-induced innate immune response and inflammation
por: Ganaie, Safder S., et al.
Publicado: (2023)

Correction: Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
por: Kay, Christine N., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_oals46i0nj8q3iqkib5i2lu20q