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Pathways of Resistance to Thymineless Death in Escherichia coli and the Function of UvrD

Thymineless death (TLD) is the rapid loss of viability in bacterial, yeast, and human cells starved of thymine. TLD is the mode of action of common anticancer drugs and some antibiotics. TLD in Escherichia coli is accompanied by blocked replication and chromosomal DNA loss and recent work identified...

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Detalles Bibliográficos
Autores principales: Fonville, Natalie C., Vaksman, Zalman, DeNapoli, Jessica, Hastings, P. J., Rosenberg, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176125/
https://www.ncbi.nlm.nih.gov/pubmed/21705756
http://dx.doi.org/10.1534/genetics.111.130161