Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI

BACKGROUND: The anaerobe Clostridium difficile produces two major virulence factors toxin A and B that inactivate Rho proteins by glucosylation of a pivotal threonine residue. Purified toxins induce reorganization of the cytoskeleton and cell death in colonic cells. Whether all toxin effects on targ...

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Detalles Bibliográficos
Autores principales: Jochim, Nelli, Gerhard, Ralf, Just, Ingo, Pich, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176154/
https://www.ncbi.nlm.nih.gov/pubmed/21849038
http://dx.doi.org/10.1186/1477-5956-9-48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176154/
https://www.ncbi.nlm.nih.gov/pubmed/21849038
http://dx.doi.org/10.1186/1477-5956-9-48

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