Degradation of HIF-1alpha under Hypoxia Combined with Induction of Hsp90 Polyubiquitination in Cancer Cells by Hypericin: a Unique Cancer Therapy

The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting diverse crossroads of cancer-promoting processes via unique mechanisms. Hypericin is the only known exogenous reagent that can induce forced poly-...

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Detalles Bibliográficos
Autores principales: Barliya, Tilda, Mandel, Mathilda, Livnat, Tami, Weinberger, Dov, Lavie, Gad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176203/
https://www.ncbi.nlm.nih.gov/pubmed/21949677
http://dx.doi.org/10.1371/journal.pone.0022849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176203/
https://www.ncbi.nlm.nih.gov/pubmed/21949677
http://dx.doi.org/10.1371/journal.pone.0022849

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