Human NK Cells Differ More in Their KIR2DL1-Dependent Thresholds for HLA-Cw6-Mediated Inhibition than in Their Maximal Killing Capacity

In this study we have addressed the question of how activation and inhibition of human NK cells is regulated by the expression level of MHC class I protein on target cells. Using target cell transfectants sorted to stably express different levels of the MHC class I protein HLA-Cw6, we show that indu...

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Detalles Bibliográficos
Autores principales: Almeida, Catarina R., Ashkenazi, Amit, Shahaf, Gitit, Kaplan, Deborah, Davis, Daniel M., Mehr, Ramit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176315/
https://www.ncbi.nlm.nih.gov/pubmed/21949790
http://dx.doi.org/10.1371/journal.pone.0024927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176315/
https://www.ncbi.nlm.nih.gov/pubmed/21949790
http://dx.doi.org/10.1371/journal.pone.0024927

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