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Structural Basis for Distinct Binding Properties of the Human Galectins to Thomsen-Friedenreich Antigen

The Thomsen-Friedenreich (TF or T) antigen, Galβ1-3GalNAcα1-O-Ser/Thr, is the core 1 structure of O-linked mucin type glycans appearing in tumor-associated glycosylation. The TF antigen occurs in about 90% of human cancer cells and is a potential ligand for the human endogenous galectins. It has bee...

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Detalles Bibliográficos
Autores principales: Bian, Cheng-Feng, Zhang, Ying, Sun, Hui, Li, De-Feng, Wang, Da-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176802/
https://www.ncbi.nlm.nih.gov/pubmed/21949831
http://dx.doi.org/10.1371/journal.pone.0025007