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Structural Basis for Distinct Binding Properties of the Human Galectins to Thomsen-Friedenreich Antigen
The Thomsen-Friedenreich (TF or T) antigen, Galβ1-3GalNAcα1-O-Ser/Thr, is the core 1 structure of O-linked mucin type glycans appearing in tumor-associated glycosylation. The TF antigen occurs in about 90% of human cancer cells and is a potential ligand for the human endogenous galectins. It has bee...
Autores principales: | Bian, Cheng-Feng, Zhang, Ying, Sun, Hui, Li, De-Feng, Wang, Da-Cheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176802/ https://www.ncbi.nlm.nih.gov/pubmed/21949831 http://dx.doi.org/10.1371/journal.pone.0025007 |
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