Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

MRCKα and MRCKβ (myotonic dystrophy kinase-related Cdc42-binding kinases) belong to a subfamily of Rho GTPase activated serine/threonine kinases within the AGC-family that regulate the actomyosin cytoskeleton. Reflecting their roles in myosin light chain (MLC) phosphorylation, MRCKα and MRCKβ influe...

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Detalles Bibliográficos
Autores principales: Heikkila, Timo, Wheatley, Edward, Crighton, Diane, Schroder, Ewald, Boakes, Alexandra, Kaye, Sarah J., Mezna, Mokdad, Pang, Leon, Rushbrooke, Mathew, Turnbull, Andrew, Olson, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176812/
https://www.ncbi.nlm.nih.gov/pubmed/21949762
http://dx.doi.org/10.1371/journal.pone.0024825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176812/
https://www.ncbi.nlm.nih.gov/pubmed/21949762
http://dx.doi.org/10.1371/journal.pone.0024825

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