Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism

Riboswitches regulate gene expression via ligand binding to an aptamer domain which induces conformational changes in a regulatory expression platform. By unfolding and refolding single add adenine riboswitch molecules in an optical trap, an integrated picture of the folding was developed and relate...

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Detalles Bibliográficos
Autores principales: Neupane, Krishna, Yu, Hao, Foster, Daniel A. N., Wang, Feng, Woodside, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177178/
https://www.ncbi.nlm.nih.gov/pubmed/21653559
http://dx.doi.org/10.1093/nar/gkr305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177178/
https://www.ncbi.nlm.nih.gov/pubmed/21653559
http://dx.doi.org/10.1093/nar/gkr305

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