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Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism
Riboswitches regulate gene expression via ligand binding to an aptamer domain which induces conformational changes in a regulatory expression platform. By unfolding and refolding single add adenine riboswitch molecules in an optical trap, an integrated picture of the folding was developed and relate...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177178/ https://www.ncbi.nlm.nih.gov/pubmed/21653559 http://dx.doi.org/10.1093/nar/gkr305 |