Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases

DNA interstrand crosslinks (ICLs), inhibit DNA metabolism by covalently linking two strands of DNA and are formed by antitumor agents such as cisplatin and nitrogen mustards. Multiple complex repair pathways of ICLs exist in humans that share translesion synthesis (TLS) past a partially processed IC...

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Detalles Bibliográficos
Autores principales: Ho, The Vinh, Guainazzi, Angelo, Derkunt, Semsi Burak, Enoiu, Milica, Schärer, Orlando D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177197/
https://www.ncbi.nlm.nih.gov/pubmed/21666254
http://dx.doi.org/10.1093/nar/gkr448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177197/
https://www.ncbi.nlm.nih.gov/pubmed/21666254
http://dx.doi.org/10.1093/nar/gkr448

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