Allosteric interactions across native adenosine-A(3) receptor homodimers: quantification using single-cell ligand-binding kinetics

A growing awareness indicates that many G-protein-coupled receptors (GPCRs) exist as homodimers, but the extent of the cooperativity across the dimer interface has been largely unexplored. Here, measurement of the dissociation kinetics of a fluorescent agonist (ABA-X-BY630) from the human A(1) or A(...

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Detalles Bibliográficos
Autores principales: May, Lauren T., Bridge, Lloyd J., Stoddart, Leigh A., Briddon, Stephen J., Hill, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2011
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177574/
https://www.ncbi.nlm.nih.gov/pubmed/21715680
http://dx.doi.org/10.1096/fj.11-186296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177574/
https://www.ncbi.nlm.nih.gov/pubmed/21715680
http://dx.doi.org/10.1096/fj.11-186296

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