Anti-DLL4, a cancer therapeutic with multiple mechanisms of action

DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4...

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Detalles Bibliográficos
Autores principales: Gurney, Austin, Hoey, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177777/
https://www.ncbi.nlm.nih.gov/pubmed/21831306
http://dx.doi.org/10.1186/2045-824X-3-18
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author Gurney, Austin
Hoey, Timothy
author_facet Gurney, Austin
Hoey, Timothy
author_sort Gurney, Austin
collection PubMed
description DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance and proliferation of cancer stem cells (CSC). In addition, its important role in angiogenesis has been investigated for utility as an anti-angiogenic agent. Preclinical studies have highlighted that both anti-CSC and anti-angiogenic activities contribute to its anti-tumor efficacy, and have supported the clinical development of anti-DLL4 antibody for the treatment of cancer.
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spelling pubmed-31777772011-09-22 Anti-DLL4, a cancer therapeutic with multiple mechanisms of action Gurney, Austin Hoey, Timothy Vasc Cell Review DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance and proliferation of cancer stem cells (CSC). In addition, its important role in angiogenesis has been investigated for utility as an anti-angiogenic agent. Preclinical studies have highlighted that both anti-CSC and anti-angiogenic activities contribute to its anti-tumor efficacy, and have supported the clinical development of anti-DLL4 antibody for the treatment of cancer. BioMed Central 2011-08-10 /pmc/articles/PMC3177777/ /pubmed/21831306 http://dx.doi.org/10.1186/2045-824X-3-18 Text en Copyright ©2011 Gurney and Hoey; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gurney, Austin
Hoey, Timothy
Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
title Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
title_full Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
title_fullStr Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
title_full_unstemmed Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
title_short Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
title_sort anti-dll4, a cancer therapeutic with multiple mechanisms of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177777/
https://www.ncbi.nlm.nih.gov/pubmed/21831306
http://dx.doi.org/10.1186/2045-824X-3-18
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